Pharmacological Disruption of Insulin-like Growth Factor 1

"A small, nonpeptide pharmacological inhibitor of IGF/IGFBP interaction restored or enhanced the IGF-1-dependent proteoglycan synthesis by human osteoarthritic chondrocytes. This finding offers a rationale for pharmacological intervention in the treatment of cartilage repair in osteoarthritis and potentially of other joint-related diseases and shows that IGFBPs are pertinent target candidates for this purpose."