An Association Between Homocysteine and Fractures

"These findings suggest an association between homocysteine levels and fractures in elders, but whether this association is causal is unclear. One causal theory holds that homocysteine interferes with collagen cross-linking and thereby weakens bone. Alternatively, homocysteine might be an innocent bystander: That is, dietary or metabolic abnormalities that result in elevated plasma homocysteine levels also might predispose to fractures. The practical question, which hasn't been studied, is whether homocysteine-lowering therapies (e.g., folic acid supplementation) lower fracture risk."